This experimental-statistical study investigates the influence of laser cladding parameters—laser power (700–900 W), scanning speed (6–8 mm/s), and wire feed rate (70–80 mm/min)—on the geometric characteristics of single-pass coatings of 2507 duplex stainless steel on a VCN200 substrate. Experimental data were analyzed using Response Surface Methodology (RSM) with a three-factor, four-level design matrix. Measurements including clad width (W), height (H), penetration depth (b), wettability angle (Z), and dilution percentage (D) were obtained via ImageJ software. Results indicated that increasing laser power from 700 to 900 W led to a 14% increase in clad width (from 1417 to 1744 µm), a 33% rise in clad height (from 450 to 594 µm), a 6% increase in penetration depth (from 88 to 93 µm), and a 3% improvement in wettability angle (from 71° to 69°). In contrast, increasing scanning speed from 6 to 8 mm/s reduced clad width by 12% (from 1513 to 1787 µm), clad height by 31% (from 650 to 573 µm), and wettability angle by 15% (from 67° to 78°), while enhancing penetration depth by 4% (from 85 to 84 µm) and dilution by 19% (from 58% to 53%). Moreover, raising the wire feed rate from 70 to 80 mm/min increased clad height by 13% (from 502 to 747 µm) and wettability angle by 4% (from 75° to 78°), but decreased dilution by 19% (from 59% to 48%).